Format

Send to

Choose Destination
See comment in PubMed Commons below
Dev Dyn. 2010 Jan;239(1):102-14. doi: 10.1002/dvdy.22181.

Wnt modulators in the biotech pipeline.

Author information

1
OsteoGeneX Inc., Kansas City, Kansas 66160, USA.

Erratum in

  • Dev Dyn. 2010 Mar;239(3):1034.

Abstract

The purpose of this review is to provide a better understanding for the LRP co-receptor-mediated Wnt pathway signaling. Using proteomics, we have also subdivided the LRP receptor family into six sub-families, encompassing the twelve family members. This review includes a discussion of proteins containing a cystine-knot protein motif (i.e., Sclerostin, Dan, Sostdc1, Vwf, Norrin, Pdgf, Mucin) and discusses how this motif plays a role in mediating Wnt signaling through interactions with LRP.

PMID:
20014100
PMCID:
PMC3111251
DOI:
10.1002/dvdy.22181
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Wiley Icon for PubMed Central
    Loading ...
    Support Center