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Inflamm Res. 2010 Mar;59 Suppl 2:S219-21. doi: 10.1007/s00011-009-0134-3.

Histamine intolerance: a metabolic disease?

Author information

1
Department of Visceral, Transplant and Thoracic Surgery, Medical University Innsbruck, Innsbruck, Austria. hubert.schwelberger@i-med.ac.at

Abstract

OBJECTIVE:

To evaluate the evidence regarding the disease concept of histamine intolerance as a state of inadequate histamine inactivation.

METHODS:

Keyword-based systematic screening of the scientific literature and of public websites focusing on diagnostic and therapeutic procedures.

RESULTS:

Histamine intolerance is commonly diagnosed based solely on subjective reporting of symptoms instead of following systematic diagnostic procedures based on objective laboratory and physical parameters. The only effective long-term therapy is avoidance of histamine-containing food.

CONCLUSIONS:

The concept of histamine intolerance as a metabolic disease is in need of more experimental and clinical evidence and affected patients will benefit from a clear, evidence-based diagnostic and therapeutic regime.

PMID:
20012758
DOI:
10.1007/s00011-009-0134-3
[Indexed for MEDLINE]

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