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Curr Top Microbiol Immunol. 2009;339:125-46. doi: 10.1007/978-3-642-02175-6_7.

Virological and cellular roles of the transcriptional coactivator LEDGF/p75.

Author information

1
Biological Sciences Department, University of Texas, El Paso, TX 79968-0519, USA. mllano@utep.edu

Abstract

The chromatin-associated cellular proteins LEDGF/p75 and LEDGF/p52 have been implicated in transcriptional regulation, cell survival and autoimmunity. LEDGF/p75 also appears to act as a chromatin-docking factor or receptor for HIV-1 and other lentiviruses and to play a role in leukemogenesis. For both the viral and cellular roles of this protein, a key feature is its ability to act as a molecular adaptor and tether proteins to the chromatin fiber. This chapter reviews the emerging roles of LEDGF/p75 and LEDGF/p52 in diverse cellular processes and disease states.

PMID:
20012527
PMCID:
PMC3093762
DOI:
10.1007/978-3-642-02175-6_7
[Indexed for MEDLINE]
Free PMC Article

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