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Cancer Causes Control. 2010 Apr;21(4):501-11. doi: 10.1007/s10552-009-9481-1. Epub 2009 Dec 11.

Determinants of serum 25 hydroxyvitamin D levels in a nationwide cohort of blacks and non-Hispanic whites.

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1
Department of Epidemiology and Biostatistics, School of Public Health, Loma Linda University, 24785 Stewart St, Loma Linda, CA 92350, USA.

Abstract

OBJECTIVE:

To develop algorithms predicting serum 25 hydroxyvitamin D [s25(OH)D] for a large epidemiological study whose subjects come from large geographic areas, are racially diverse and have a wide range in age, skin types, and month of blood sample collection. This will allow a regression calibration approach to determine s25(OH)D levels replacing the more costly method of collection and analysis of blood samples.

STUDY DESIGN AND SETTING:

Questionnaire data from a subsample of 236 non-Hispanic whites (whites) and 209 blacks from the widely dispersed Adventist Health Study-2 (n = 96,000) were used to develop prediction algorithms for races separately and combined. A single blood sample was collected from each subject, at different times throughout the year.

RESULTS:

Models with independent variables age, sex, BMI, skin type, UV season, erythemal zone, total dietary vitamin D intake, and sun exposure factor explained 22 and 31% of the variance of s25(OH)D levels in white and black populations, respectively (42% when combined). UV season and erythemal zone determined from measured UV radiation produced models with higher R (2) than season and latitude.

CONCLUSION:

Combining races with a term for race and using variables with measured UV radiation capture the variance in s25(OH)D levels better than analyzing races separately.

PMID:
20012182
PMCID:
PMC3427006
DOI:
10.1007/s10552-009-9481-1
[Indexed for MEDLINE]
Free PMC Article
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