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Front Neurosci. 2009 Sep 15;3(2):198-205. doi: 10.3389/neuro.01.027.2009. eCollection 2009.

Hebbian reverberations in emotional memory micro circuits.

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  • 1Department of Psychiatry and Program in Neuroscience, USU Bethesda, MD, USA.

Abstract

The study of memory in most behavioral paradigms, including emotional memory paradigms, has focused on the feed forward components that underlie Hebb's first postulate, associative synaptic plasticity. Hebb's second postulate argues that activated ensembles of neurons reverberate in order to provide temporal coordination of different neural signals, and thereby facilitate coincidence detection. Recent evidence from our groups has suggested that the lateral amygdala (LA) contains recurrent microcircuits and that these may reverberate. Additionally this reverberant activity is precisely timed with latencies that would facilitate coincidence detection between cortical and sub cortical afferents to the LA. Thus, recent data at the microcircuit level in the amygdala provide some physiological evidence in support of the second Hebbian postulate.

KEYWORDS:

amygdala; ensembles; fear; network; recurrent

PMID:
20011142
PMCID:
PMC2751649
DOI:
10.3389/neuro.01.027.2009
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