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Nat Rev Microbiol. 2010 Jan;8(1):74-82. doi: 10.1038/nrmicro2243.

Mass spectrometry tools for the classification and identification of bacteria.

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Max Planck Institute for Molecular Genetics, Otto-Warburg Laboratory, Ihnestrasse 63-73, D-14195 Berlin, Germany.


Mass spectrometry has become an important analytical tool in biology in the past two decades. In principle, mass spectrometry offers high-throughput, sensitive and specific analysis for many applications in microbiology, including clinical diagnostics and environmental research. Recently, several mass spectrometry methods for the classification and identification of bacteria and other microorganisms, as well as new software analysis tools, have been developed. In this Review we discuss the application range of these mass spectrometry procedures and their potential for successful transfer into microbiology laboratories.

[Indexed for MEDLINE]

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