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Nat Mater. 2010 Jan;9(1):60-7. doi: 10.1038/nmat2596. Epub 2009 Dec 13.

Nanogap-engineerable Raman-active nanodumbbells for single-molecule detection.

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1
Department of Chemistry, Seoul National University, Seoul, 151-747, South Korea.

Abstract

Surface-enhanced Raman scattering (SERS)-based signal amplification and detection methods using plasmonic nanostructures have been widely investigated for imaging and sensing applications. However, SERS-based molecule detection strategies have not been practically useful because there is no straightforward method to synthesize and characterize highly sensitive SERS-active nanostructures with sufficiently high yield and efficiency, which results in an extremely low cross-section area in Raman sensing. Here, we report a high-yield synthetic method for SERS-active gold-silver core-shell nanodumbbells, where the gap between two nanoparticles and the Raman-dye position and environment can be engineered on the nanoscale. Atomic-force-microscope-correlated nano-Raman measurements of individual dumbbell structures demonstrate that Raman signals can be repeatedly detected from single-DNA-tethered nanodumbbells. These programmed nanostructure fabrication and single-DNA detection strategies open avenues for the high-yield synthesis of optically active smart nanoparticles and structurally reproducible nanostructure-based single-molecule detection and bioassays.

PMID:
20010829
DOI:
10.1038/nmat2596
[Indexed for MEDLINE]
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