Format

Send to

Choose Destination
See comment in PubMed Commons below
Nat Biotechnol. 2009 Dec;27(12):1151-62. doi: 10.1038/nbt.1590.

Genome engineering.

Author information

1
Massachusetts Institute of Technology, Media Lab, Center for Bits and Atoms, Massachusetts, Cambridge, USA. carr@media.mit.edu

Abstract

For more than 50 years, those engineering genetic material have pursued increasingly challenging targets. During that time, the tools and resources available to the genetic engineer have grown to encompass new extremes of both scale and precision, opening up new opportunities in genome engineering. Today, our capacity to generate larger de novo assemblies of DNA is increasing at a rapid pace (with concomitant decreases in manufacturing cost). We are also witnessing potent demonstrations of the power of merging randomness and selection with engineering approaches targeting large numbers of specific sites within genomes. These developments promise genetic engineering with unprecedented levels of design originality and offer new avenues to expand both our understanding of the biological world and the diversity of applications for societal benefit.

PMID:
20010598
DOI:
10.1038/nbt.1590
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Nature Publishing Group
    Loading ...
    Support Center