Format

Send to

Choose Destination
AIDS. 2010 Jan 16;24(2):271-82. doi: 10.1097/QAD.0b013e328333ddee.

Transmission networks of HIV-1 among men having sex with men in the Netherlands.

Collaborators (168)

Prins JM, Bos JC, Eeftinck-Schattenkerk JK, Geerlings SE, Godfried MH, Lange JM, van der Meer JT, Nellen FJ, Olszyna DP, van der Poll T, Reiss P, Sankatsing SU, Steingrover R, van der Valk M, Vermeulen JN, Vrouenraets SM, van Vugt M, Schrei G, van der Geest S, Oude Lashof A, Lowe S, Verbon A, Bravenboer B, Pronk MJ, Kuijpers TW, Pajkrt D, Scherpbier HJ, van der Ende ME, Bax H, van der Feltz M, Gelinck LB, de Melo M, Nouwen JL, Rijnders BJ, de Ruiter ED, Slobbe L, Schurink CA, de Vries TE, Driessen G, van der Flier M, Hartwig NG, Branger J, Kauffmann RH, Pogany K, Schippers EF, Groeneveld PH, Alleman MA, ten Kate RW, Soetekouw R, Kroon FP, Arend SM, de Boer MG, van den Broek PJ, van Dissel JT, van Nieuwkoop C, den Hollander JG, Bronsveld W, Vriesendorp R, Jeurissen FJ, Leyten EM, van Houte D, Polee MB, ten Napel CH, Kootstra GJ, Brinkman K, van den Berk GE, Blok WL, Frissen PH, Schouten WE, van Eeden A, Verhagen DW, Mulde JW, van Gorp EC, Mairuhu AT, Steingrover R, Wagenaar J, Juttmann JR, van Kasteren ME, Veenstra J, Vasmel WL, Koopmans PP, Brouwer AM, Dofferhoff AS, de Groot R, ter Hofstede HJ, Keuter M, van der Ven AJ, Sprenger HG, van Assen S, van Leeuwen JT, Stek CJ, Doedens R, Scholvinck EH, Hoepelman IM, Schneider MM, Bonten MJ, Ellerbroek PM, Jaspers CA, Maarschalk-Ellerbroek LJ, Oosterheert JJ, Peters EJ, Mudrikova T, Wassenberg MW, Weijer S, Geelen SP, Wolfs TF, Danner SA, van Agtmael MA, Bierman WF, Claessen FA, Hillebrand ME, de Jong EV, Kortmann W, Perenboom RM, bij de Vaate EA, Richter C, van der Berg J, Gisolf EH, Tanis AA, Duits AJ, Winkel K, Back NK, Bakker ME, Zaaijer HL, Berkhout B, Jurriaans S, Cuijpers T, Rietra PJ, Roozendaal KJ, Pauw W, Smits PH, van Zanten AP, von Blomberg BM, Pettersson A, Savelkoul P, Swanink CM, Franck PF, Lampe AS, Jansen CL, Hendriks R, Benne CA, Schirm J, Veenendaal D, Storm H, Weel J, van Zeijl JH, Claas HC, Kroes AC, Bruggeman CA, Goossens VJ, Galama JM, Melchers WJ, Lunel V, van Doornum GJ, Niesters HG, Osterhaus AD, Schutten M, Buiting AG, Boucher CA, Boel E, Schuurman R, Jansz AF, Wulf M, Veldkamp A, Beijnen JH, Huitema AD, Burger DM, van Kan HJ.

Author information

1
HIV Monitoring Foundation, Academic Medical Centre, Amsterdam, The Netherlands. D.O.Bezemer@amc.uva.nl

Abstract

OBJECTIVE:

To obtain insight in the HIV-1 transmission networks among men having sex with men (MSM) in the Netherlands.

DESIGN:

A phylogenetic tree was constructed from polymerase sequences isolated from 2877 HIV-1 subtype B-infected patients monitored as part of the AIDS Therapy Evaluation in the Netherlands (ATHENA) nationwide observational cohort.

METHODS:

For MSM with a known date of infection, the most similar sequences were selected as potential transmission pairs when they clustered with bootstrap value of at least 99%. Time from infection to onward transmission was estimated as the median time between dates of infection for each transmission pair. The source of infections with a resistant strain was traced using the entire phylogenetic tree.

RESULTS:

Of sequences from 403 MSM with a known date of infection between 1987 and 2007, 175 (43%) formed 63 clusters. Median time to onward transmission was 1.4 years (interquartile range 0.6-2.7). Twenty-four (6%) MSM carried a virus with resistance-related mutations, 13 of these were in eight clusters together with sequences from 28 other patients in the entire phylogenetic tree. Six clusters contained sequences obtained from 29 men all presenting the same resistance-related mutations.

CONCLUSION:

From our selection of likely transmission pairs, we conclude that onward transmission of HIV-1 from infected MSM in the Netherlands happens both during and after primary infection. Transmission of resistant strains from the antiretroviral therapy-treated population is limited, but strains with resistance-related mutations have formed subepidemics.

PMID:
20010072
DOI:
10.1097/QAD.0b013e328333ddee
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Wolters Kluwer
Loading ...
Support Center