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Arterioscler Thromb Vasc Biol. 2010 Mar;30(3):533-5. doi: 10.1161/ATVBAHA.109.200097. Epub 2009 Dec 10.

A specific subset of mouse bone marrow cells has smooth muscle cell differentiation capacity-brief report.

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1
Centre for Research in Vascular Biology, BioSciences Institute, University College Cork, College Road, Cork City, Ireland.

Abstract

OBJECTIVE:

To determine whether CX(3)CR1(+) bone marrow cells have the capacity for smooth muscle cell (SMC) differentiation.

METHODS AND RESULTS:

CX(3)CR1(+) and CX(3)CR1(-) cells were isolated from marrow of CX(3)CR1 transgenic mice and cultured in SMC differentiation media. Phenotypic and functional analyses showed only CX(3)CR1(+) bone marrow cells exhibit colony cell outgrowth with SMC-specific protein expression, calcium signaling, and contraction responses similar to mature SMC.

CONCLUSIONS:

CX(3)CR1 marks a bone marrow cells population that enriches for progenitors with capacity to differentiate in vitro into SMC-like cells.

PMID:
20007909
DOI:
10.1161/ATVBAHA.109.200097
[Indexed for MEDLINE]
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