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Cell Host Microbe. 2009 Dec 17;6(6):493-5. doi: 10.1016/j.chom.2009.12.001.

Regulatory natural killer cells: new players in the IL-10 anti-inflammatory response.

Author information

1
Centre d'Immunologie de Marseille-Luminy, Université de la Méditerranée, Marseille 13288, France. vivier@ciml.univ-mrs.fr

Abstract

Natural Killer (NK) cells boost immune defense via their cytolytic activity and their capacity to produce interferon-gamma. Now Perona-Wright et al. (2009), in this issue of Cell Host & Microbe, show that NK cells can also dampen immune responses to diverse pathogens via secretion of the anti-inflammatory cytokine interleukin-10. Remarkably, this immunosuppressive activity only occurs during systemic infections.

PMID:
20006835
DOI:
10.1016/j.chom.2009.12.001
[Indexed for MEDLINE]
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