Format

Send to

Choose Destination
See comment in PubMed Commons below
Fitoterapia. 2010 Jul;81(5):420-3. doi: 10.1016/j.fitote.2009.12.002. Epub 2009 Dec 16.

A bioactive isoprenylated xanthone and other constituents of Garcinia edulis.

Author information

  • 1Department of Natural Product Development and Formulations, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania. magadulajanguj@yahoo.com

Abstract

Phytochemical investigation on the root bark of Garcinia edulis (Clusiaceae) gave a new isoprenylated xanthone, 1,4,6-trihydroxy-3-methoxy-2-(3-methyl-2-butenyl)-5-(1,1-dimethyl-prop-2-enyl)xanthone (1), a known xanthone, forbexanthone (2) together with three known pentacyclic triterpenoids, friedelin, lupeol and lupeol acetate. The structure of the new compound was fully characterised by NMR spectroscopic analysis. Compound 1 showed significant anti-HIV-1 protease activity with IC(50) value of 11.3 microg/mL. Furthermore, compound 1 showed potent cytotoxic activity with LC(50) value of 2.36 microg/mL against brine shrimp larva in vitro.

PMID:
20006684
DOI:
10.1016/j.fitote.2009.12.002
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center