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Mol Cell. 2009 Dec 11;36(5):715-9. doi: 10.1016/j.molcel.2009.11.030.

Reverse transcribing the code for chromosome stability.

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1
Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA. sartandi@stanford.edu

Abstract

The linearity of eukaryotic chromosomes presents challenges to cells, as the presence of DNA "ends" poses problems for the DNA replication machinery and the cell's damage response systems. This year's Nobel Prize in Physiology or Medicine recognized groundbreaking studies establishing the telomere field as a crucial area of biomedical research.

PMID:
20005831
DOI:
10.1016/j.molcel.2009.11.030
[Indexed for MEDLINE]
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