Format

Send to

Choose Destination
Neuron. 2009 Dec 10;64(5):645-62. doi: 10.1016/j.neuron.2009.10.017.

A cluster of cholinergic premotor interneurons modulates mouse locomotor activity.

Author information

1
Howard Hughes Medical Institute, Kavli Institute for Brain Science, Department of Neuroscience, Columbia University, New York, NY 10032, USA.

Abstract

Mammalian motor programs are controlled by networks of spinal interneurons that set the rhythm and intensity of motor neuron firing. Motor neurons have long been known to receive prominent "C bouton" cholinergic inputs from spinal interneurons, but the source and function of these synaptic inputs have remained obscure. We show here that the transcription factor Pitx2 marks a small cluster of spinal cholinergic interneurons, V0(C) neurons, that represents the sole source of C bouton inputs to motor neurons. The activity of these cholinergic interneurons is tightly phase locked with motor neuron bursting during fictive locomotor activity, suggesting a role in the modulation of motor neuron firing frequency. Genetic inactivation of the output of these neurons impairs a locomotor task-dependent increase in motor neuron firing and muscle activation. Thus, V0(C) interneurons represent a defined class of spinal cholinergic interneurons with an intrinsic neuromodulatory role in the control of locomotor behavior.

PMID:
20005822
PMCID:
PMC2891428
DOI:
10.1016/j.neuron.2009.10.017
[Indexed for MEDLINE]
Free PMC Article

Publication types, MeSH terms, Substances, Grant support

Publication types

MeSH terms

Substances

Grant support

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center