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Adv Chronic Kidney Dis. 2010 Jan;17(1):59-71. doi: 10.1053/j.ackd.2009.08.013.

The treatment of HIV-associated nephropathy.

Author information

1
MetroHealth Medical Center and Case Western Reserve University School of Medicine, Cleveland, OH, USA.

Abstract

Antiretroviral therapy (ART) preserves kidney function in patients with human immunodeficiency virus (HIV)-associated nephropathy (HIVAN). Emerging data also document substantial renal benefits of ART in the general HIV-infected population, which is associated in part with suppression of HIV-1 viral replication. The extent to which the response to ART differs in persons with HIVAN compared with those with other HIV-associated kidney disorders is unknown. Beneficial effects of corticosteroids and angiotensin-converting enzyme inhibitors on kidney function also are suggested by retrospective cohort studies and uncontrolled trials of patients with HIVAN. Underexposure to ART or inadequate ART dosing in HIV-infected patients with CKD may curtail the optimal benefits that may be derived from this therapy.

PMID:
20005490
PMCID:
PMC2811489
DOI:
10.1053/j.ackd.2009.08.013
[Indexed for MEDLINE]
Free PMC Article

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