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Semin Immunol. 2010 Feb;22(1):54-8. doi: 10.1016/j.smim.2009.11.002. Epub 2009 Dec 11.

How Hydra senses and destroys microbes.

Author information

1
Zoological Institute, Christian-Albrechts-University Kiel, Olshausenstrasse 40, 24098 Kiel, Germany.

Abstract

Molecular genetic evidence has revealed that the basic templates of innate immune sensors were laid down in ancient animals such as the cnidarian Hydra. Important functions of Hydra's innate immune sensors and effectors include not only protection against pathogens but also controlling tissue-microbiota homeostasis. The deep evolutionary connections imply that invertebrate and mammalian immune pathways have evolved from a reduced number of common ancestral building blocks to their present configurations.

PMID:
20005124
DOI:
10.1016/j.smim.2009.11.002
[Indexed for MEDLINE]

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