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J Allergy Clin Immunol. 2009 Dec;124(6):1251-8.e23. doi: 10.1016/j.jaci.2009.10.009.

Global variations in prevalence of eczema symptoms in children from ISAAC Phase Three.

Collaborators (264)

Aït-Khaled N, Anderson HR, Asher MI, Beasley R, Björkstén B, Brunekreef B, Crane J, Ellwood P, Flohr C, Foliaki S, García-Marcos L, Keil U, Lai CK, Mallol J, Mitchell EA, Montefort S, Pearce N, Robertson CF, Stewart AW, Strachan D, von Mutius E, Weiland SK, Weinmayr G, Williams H, Wong G, Asher MI, Clayton TO, Ellwood P, Mitchell EA, Stewart AW, Priftanji A, Benhabylès B, Baena-Cagnani CE, Crisci CD, Zabert GE, Robertson CF, Haidinger G, Howitt ME, Weyler J, Pinto-Vargas R, Bernhardt CD, Borges WG, Camargos PA, Cardoso MD, Cunha AJ, Fischer GB, Motta JM, Neto AP, Passos FJ, Pastorino AC, Rosário N, Silva A, Solé D, Wandalsen N, de Britto M, Souza Lde F, Popov T, Kuaban C, Ferguson A, Rennie D, Goulding R, Standring P, Aguilar P, Amarales L, Benavides LA, Calvo MA, Contreras A, Chen YZ, Kunii O, Pan QL, Zhong NS, Aristizábal G, Cepeda AM, Ordoñez GA, M'Boussa J, Daniel R, Soto-Quirós ME, Koffi BN, Tomulic KL, Peréz PV, Barba S, Bustos C, Naguib ML, Figueroa M, Riikjärv MA, Melaku K, Sa'aga-Banuve R, Pekkanen J, Vlaski E, Hypolite IE, Gotua M, Keil U, Tsanakas J, Bueso-Engelhardt A, Lau YL, Wong G, Novák Z, Zsigmond G, Awasthi S, Bhave S, Chhatwal J, Hanumante NM, Jain KC, Joshi MK, Khatav VA, Kumar L, Mantri SN, Pherwani AV, Rego S, Sabir M, Salvi S, Setty G, Sharma SK, Singh V, Sukumaran TU, Babu PS, Kartasasmita CB, Konthen P, Suprihati W, Masjedi MR, Steriu A, Armenio L, Bisanti L, Bonci E, Chellini E, Ciccone G, Dell'Orco V, Forastiere F, Galassi C, Giannella G, La Grutta S, Petronio MG, Piffer S, Sestini P, Abu-Ekteish F, Esamai FO, Ng'ang'a L, Foliaki S, al-Momen JA, Imanalieva C, Sulaimanov S, Svabe V, Bojarskas J, Kudzyte J, Quah BS, Teh KH, de Bruyne J, Montefort S, Baeza-Bacab M, Barragán-Meijueiro M, Del-Río-Navarro BE, García-Almaraz R, González-Díaz SN, Linares-Zapién FJ, Merida-Palacio JV, Ramírez-Chanona N, Romero-Tapia S, Romieu I, Bouayad Z, Engels R, Asher I, MacKay R, Moyes C, Pattemore P, Pearce N, Sánchez JF, Onadeko BO, Magatogia M, Annesi-Maesano I, Mahmood N, Yusuf MO, El Sharif N, Mortaja S, Cukier G, Guggiari-Chase JA, Chiarella P, Cua-Lim F, Brêborowicz A, Lis G, Annesi-Maesano I, Chiera ML, Câmara R, dos Santos JM, Nunes C, Pinto JE, Clancy L, Kayembe JM, Annesi-Maesano I, Deleanu D, Kondiourina EG, Sow OY, Fuimaono P, Adzovic O, Hadnadjev M, Panic E, Zivanovic S, Zivkovic Z, Goh DY, Voyi K, Zar HJ, Lee HB, Arnedo-Pena A, Batlles-Garrido J, Quirós AB, Busquets RM, Carvajal-Urueña I, Garcia-Hernández G, García-Marcos L, Díaz CG, Guillén-Grima F, Varela AL, Suárez-Varela MM, Pérez-Yarza EG, Gunasekera KD, Musa OA, Al-Rawas O, Vogt H, Mohammad S, Mohammad Y, Tabbah K, Huang JL, Kao CC, Kongpanichkul A, Nettagul R, Prasarnphanich T, Teeratakulpisarn J, Trakultivakorn M, Vichyanond P, Tidjani O, Iosefa T, Monteil MA, Jerray M, Khaldi F, Redding GJ, Windom HH, Ognev V, Anderson HR, Austin JB, Shamssain MH, Strachan D, Holgado D, Lapides MC, Aldrey O, Cam BV, Sears M, Anderson HR, Aguirre V, Ahel V, Gratziou C, Lai CK, Shah J, Baratawidjaja K, Anderson HR, Fakakovi T, Otten R, Barny S, Chansin R, Manning P, Bahati E, Khaitov RM, Tuuau-Potai N, Lee BW, El Sony A, Nilsson L.

Author information

1
Centre for Respiratory Diseases Research, Kenya Medical Research Institute, Nairobi, Kenya.

Abstract

BACKGROUND:

In 1999, The International Study of Asthma and Allergies in Childhood (ISAAC) Phase One reported the prevalence of eczema symptoms in 715,033 children from 154 centers in 56 countries by using standardized epidemiologic tools.

OBJECTIVE:

To update the world map of eczema prevalence after 5 to 10 years (ISAAC Phase Three) and include additional data from over 100 new centers.

METHODS:

Cross-sectional surveys using the ISAAC questionnaire on eczema symptoms were completed by adolescents 13 to 14 years old and by parents of children 6 to 7 years old. Current eczema was defined as an itchy flexural rash in the past 12 months and was considered severe eczema if associated with 1 or more nights per week of sleep disturbance.

RESULTS:

For the age group 6 to 7 years, data on 385,853 participants from 143 centers in 60 countries showed that the prevalence of current eczema ranged from 0.9% in India to 22.5% in Ecuador, with new data showing high values in Asia and Latin America. For the age group 13 to 14 years, data on 663,256 participants from 230 centers in 96 countries showed prevalence values ranging from 0.2% in China to 24.6% in Columbia with the highest values in Africa and Latin America. Current eczema was lower for boys than girls (odds ratio, 0.94 and 0.72 at ages 6 to 7 years and 13 to 14 years, respectively).

CONCLUSION:

ISAAC Phase Three provides comprehensive global data on the prevalence of eczema symptoms that is essential for public health planning. New data reveal that eczema is a disease of developing as well as developed countries.

PMID:
20004783
DOI:
10.1016/j.jaci.2009.10.009
[Indexed for MEDLINE]

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