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Microbes Infect. 2010 Mar;12(3):173-81. doi: 10.1016/j.micinf.2009.12.001. Epub 2010 Feb 1.

Immune responses to Epstein-Barr virus: molecular interactions in the virus evasion of CD8+ T cell immunity.

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1
Cancer Research UK Birmingham Cancer Centre, University of Birmingham, College of Medical and Dental Sciences, Vincent Drive, Edgbaston, Birmingham B15 2TT, United Kingdom. m.rowe@bham.ac.uk

Abstract

Persistent viruses have mechanisms for modulating the host immune responses that are essential for achieving a lifelong virus-host balance while minimizing the viral pathogenicity. Here we review some of the immune-modulating mechanisms evolved by the ubiquitous but potentially oncogenic Epstein-Barr virus, with particular emphasis on the molecular mechanisms of genes interfering with HLA class I antigen presentation.

PMID:
20004735
PMCID:
PMC2832755
DOI:
10.1016/j.micinf.2009.12.001
[Indexed for MEDLINE]
Free PMC Article
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