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Bioorg Med Chem Lett. 2010 Jan 1;20(1):161-3. doi: 10.1016/j.bmcl.2009.11.026. Epub 2009 Nov 13.

Investigation of the sequence and length dependence for cell-penetrating prenylated peptides.

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  • 1Department of Chemistry, University of Minnesota, 207 Pleasant Street SE, Minneapolis, MN 55455, USA.

Abstract

Cell penetrating peptides are useful delivery tools for introducing molecules of interest into cells. A new class of cell penetrating molecules has been recently reported-cell penetrating, prenylated peptides. In this study a series of such peptides was synthesized to examine the relationship between peptide sequence and level of peptide internalization and to probe their mechanism of internalization. This study revealed that prenylated peptides internalize via a non-endocytotic pathway regardless of sequence. Sequence length and identity was found to play a role in peptide uptake but prenylated sequences as short as two amino acids were found to exhibit significant cell penetrating properties.

PMID:
20004573
PMCID:
PMC2834556
DOI:
10.1016/j.bmcl.2009.11.026
[PubMed - indexed for MEDLINE]
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