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Cytokine Growth Factor Rev. 2010 Feb;21(1):27-39. doi: 10.1016/j.cytogfr.2009.11.007. Epub 2009 Dec 8.

The chemokine system in cancer biology and therapy.

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1
Department of Translational Medicine, University of Milan, I-20089 Rozzano, Milan, Italy. alberto.mantovani@humanitas.it <alberto.mantovani@humanitas.it>

Abstract

Chemokines are a key component of cancer-related inflammation. Chemokines and chemokine receptors are downstream of genetic events that cause neoplastic transformation and are components of chronic inflammatory conditions, which predispose to cancer. Components of the chemokine system affect in a cell autonomous or non-autonomous way multiple pathways of tumor progression, including: leukocyte recruitment and function; cellular senescence; tumor cell proliferation and survival; invasion and metastasis. Available information in preclinical and clinical settings suggests that the chemokine system represents a valuable target for the development of innovative therapeutic strategies.

PMID:
20004131
DOI:
10.1016/j.cytogfr.2009.11.007
[Indexed for MEDLINE]
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