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Biochem J. 2009 Dec 14;425(1):13-26. doi: 10.1042/BJ20091181.

Molecular mechanisms of metabolic regulation by insulin in Drosophila.

Author information

1
German Cancer Research Center (Deutsches Krebsforschungszentrum), Im Neuenheimer Feld 580, 69120 Heidelberg, Germany. a.teleman@dkfz.de

Abstract

The insulin signalling pathway is highly conserved from mammals to Drosophila. Insulin signalling in the fly, as in mammals, regulates a number of physiological functions, including carbohydrate and lipid metabolism, tissue growth and longevity. In the present review, I discuss the molecular mechanisms by which insulin signalling regulates metabolism in Drosophila, comparing and contrasting with the mammalian system. I discuss both the intracellular signalling network, as well as the communication between organs in the fly.

PMID:
20001959
DOI:
10.1042/BJ20091181
[Indexed for MEDLINE]

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