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Growth Factors. 2010 Apr;28(2):111-6. doi: 10.3109/08977190903468185.

Evidence on the use of platelet-rich plasma for diabetic ulcer: a systematic review.

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Department of Continuing Education, A. C. Camargo Cancer Hospital, São Paulo, Brazil.


The aim of topical wound treatment is to favor efficient, rapid, and safe healing. The platelet-rich plasma (PRP) has been used for wound treatment since it contains various platelet growth factors. The objective of the present study was to collect evidence regarding the use of PRP for the topical treatment of chronic leg ulcers. For this purpose, a systematic review of the literature was performed according to the steps recommended by the Cochrane Collaboration with studies published until July 2008. Among 18 selected studies, 7 (39%) of these studies were randomized clinical. Five of the seven randomized clinical trials studied ulcers of diabetic etiology. The results of meta-analysis showed that PRP favors the healing process (95% CI: 2.94-20.31). In conclusion, the present systematic review and meta-analysis show that there is a scientific evidence regarding favorable outcomes of the use of PRP for the treatment of diabetic ulcer.

[Indexed for MEDLINE]

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