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Expert Opin Ther Targets. 2010 Jan;14(1):45-55. doi: 10.1517/14728220903431069.

The NF-kappaB activation pathways, emerging molecular targets for cancer prevention and therapy.

Author information

1
Molecular Biology and Lung Cancer Program, Lovelace Respiratory Research Institute, Albuquerque, NM 87108, USA. ylin@lrri.org

Abstract

IMPORTANCE OF THE FIELD:

Nuclear factor kappa B (NF-kappaB) is activated by a variety of cancer-promoting agents. The reciprocal activation between NF-kappaB and inflammatory cytokines makes NF-kappaB important for inflammation-associated cancer development. Both the constitutive and anticancer therapeutic-induced NF-kappaB activation blunts the anticancer activities of the therapy. Elucidating the roles of NF-kappaB in cancer facilitates developing approaches for cancer prevention and therapy.

AREAS COVERED IN THIS REVIEW:

By searching PubMed, we summarize the progress of studies on NF-kappaB in carcinogenesis and cancer cells' drug resistance in recent 10 years.

WHAT THE READER WILL GAIN:

The mechanisms by which NF-kappaB activation pathways are activated; the roles and mechanisms of NF-kappaB in cell survival and proliferation, and in carcinogenesis and cancer cells' response to therapy; recent development of NF-kappaB-modulating means and their application in cancer prevention and therapy.

TAKE HOME MESSAGE:

NF-kappaB is involved in cancer development, modulating NF-kappaB activation pathways has important implications in cancer prevention and therapy. Due to the complexity of NF-kappaB roles in different cancers, careful evaluation of NF-kappaB's in each cancer type is crucial in this regard. More cancer cell-specific NF-kappaB inhibiting means are desired for improving anticancer efficacy and reducing systemic toxicity.

PMID:
20001209
PMCID:
PMC3043547
DOI:
10.1517/14728220903431069
[Indexed for MEDLINE]
Free PMC Article

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