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Pediatr Blood Cancer. 2010 Apr;54(4):621-3. doi: 10.1002/pbc.22363.

Pseudometastasis secondary to histoplasmosis infection: false-positive PET/CT findings.

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Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota, USA.


Positron emission computed tomography (PET)/CT is a common modality used in the workup of neoplastic conditions. However, false-positive results may be produced by underlying infectious processes. We report two cases of false-positive PET/CT studies secondary to histoplasmosis infections in both a pediatric and a young adult patient. After the diagnoses, one patient was observed with no therapy and the other received a complete course of itraconazole. In both cases biopsy results were positive for fungal elements consistent with histoplasmosis. Both patients were successfully managed and have had follow-up histoplasmosis titers that reveal resolving infections.

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