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Nat Rev Neurosci. 2010 Jan;11(1):30-43. doi: 10.1038/nrn2756. Epub 2009 Dec 9.

The cerebellar microcircuit as an adaptive filter: experimental and computational evidence.

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Department of Psychology, University of Sheffield, Western Bank, Sheffield, S10 2TP, UK.


Initial investigations of the cerebellar microcircuit inspired the Marr-Albus theoretical framework of cerebellar function. We review recent developments in the experimental understanding of cerebellar microcircuit characteristics and in the computational analysis of Marr-Albus models. We conclude that many Marr-Albus models are in effect adaptive filters, and that evidence for symmetrical long-term potentiation and long-term depression, interneuron plasticity, silent parallel fibre synapses and recurrent mossy fibre connectivity is strikingly congruent with predictions from adaptive-filter models of cerebellar function. This congruence suggests that insights from adaptive-filter theory might help to address outstanding issues of cerebellar function, including both microcircuit processing and extra-cerebellar connectivity.

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