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FEBS Lett. 2010 Feb 5;584(3):562-6. doi: 10.1016/j.febslet.2009.12.002. Epub 2009 Dec 6.

Mitochondria-targeted antioxidant SkQR1 selectively protects MDR (Pgp 170)-negative cells against oxidative stress.

Author information

1
A N Belozersky Institute of Physico-Chemical Biology and Institute of Mitoengineering, M V Lomonosov Moscow State University, Moscow, Russia.

Abstract

A conjugate of plastoquinone with decylrhodamine 19 (SkQR1) selectively accumulates in mitochondria of normal and tumor cells. SkQR1 protected the cellular pool of reduced glutathione under oxidative stress. Overexpression of P-glycoprotein (Pgp 170) multidrug resistance pump strongly suppresses accumulation of SkQR1. The inhibitors of Pgp 170 stimulate accumulation of SkQR1 in various cell lines indicating that SkQR1 is a substrate of Pgp 170. The protective effect of SkQR1 against oxidative stress is diminished in the cells overexpressing Pgp 170. It is suggested that mitochondria-targeted antioxidants could selectively protect normal (Pgp 170-negative) cells against the toxic effect of anti-cancer treatments related to oxidative stress.

PMID:
19995561
DOI:
10.1016/j.febslet.2009.12.002
[Indexed for MEDLINE]
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