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Biochem Biophys Res Commun. 2010 Jan 1;391(1):1039-42. doi: 10.1016/j.bbrc.2009.12.014. Epub 2009 Dec 6.

The novel function of nesfatin-1: anti-hyperglycemia.

Author information

1
Institute of Molecular & Experimental Therapeutics, East China Normal University, Shanghai 200062, China.

Abstract

Nesfatin-1 is recently reported as a satiety molecule to suppress food intake via the melanocortin signaling in hypothalamus when injected centrally and peripherally. Here we report that nesfatin-1 is also anti-hyperglycemic. It was found that the intravenous injection of nesfatin-1 significantly reduced blood glucose in hyperglycemic db/db mice. This anti-hyperglycemic effect of nesfatin-1 was time-, dose-, insulin-dependent and peripheral.

PMID:
19995555
DOI:
10.1016/j.bbrc.2009.12.014
[Indexed for MEDLINE]

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