Send to

Choose Destination
Br J Haematol. 2010 Feb;148(4):507-21. doi: 10.1111/j.1365-2141.2009.08021.x. Epub 2009 Dec 8.

Haemostasis and thrombosis in liver disease.

Author information

King's Thrombosis Centre, King's College Hospital NHS Foundation Trust, Denmark Hill, London, UK.


Liver disease impacts on both primary and secondary haemostatic mechanisms and historically these changes were thought to underpin the bleeding diathesis. However, bleeding complications in patients with liver disease are unpredictable, with the majority of haemorrhagic episodes occurring as a result of porto-systemic varices. Thrombosis is an increasingly recognised complication and systemic hypercoagulability may contribute to the development of parenchymal extinction and accelerated hepatic fibrosis. Routine laboratory tests do not reliably predict the risk of haemorrhage and the optimal management strategy to avert potential bleeding complications is yet to be established. There may be a future role for global coagulation assays, such as thrombelastography and thrombin generation, in both stratifying the risk of bleeding and guiding management of these patients.

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center