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Future Microbiol. 2009 Dec;4(10):1337-52. doi: 10.2217/fmb.09.102.

Structural and functional role of Staphylococcus aureus surface components recognizing adhesive matrix molecules of the host.

Author information

1
Department of Biochemistry, 27100 Pavia, Italy. pspeziale@unipv.it

Abstract

Staphylococcus aureus is a versatile and harmful human pathogen in both hospital- and community-acquired infections. S. aureus can initiate host infection by adhering to components of the extracellular matrix. Adherence is mediated by a variety of protein adhesins of the microbial surface component recognizing adhesive matrix molecule (MSCRAMM) family. In this article, we describe these MSCRAMMs in terms of structural organization and ligand-binding capacity and discuss their role as a possible target for immunotherapy.

PMID:
19995192
DOI:
10.2217/fmb.09.102
[Indexed for MEDLINE]

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