Format

Send to

Choose Destination
See comment in PubMed Commons below
Res Commun Chem Pathol Pharmacol. 1977 Oct;18(2):283-90.

Activation of cAMP-dependent protein kinase without a corresponding increase in phosphorylase activity.

Abstract

The effect of prostaglandin E1(PGE1) and epinephrine on glycogen metabolism has been investigated in the perfused rat heart. Both agents produced increases in cAMP and the cAMP-dependent protein kinase activity ratio. When dosages were adjusted to give equal increases in the protein kinase activity ratio from a basal value of 0.15 to as high as 0.40, only epinephrine caused a significant increase in phosphorylase activity. When used together, PGE1 did not effect the ability of epinephrine to increase phosphorylase activity.

PMID:
199922
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Loading ...
    Support Center