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Bioorg Med Chem Lett. 2010 Jan 15;20(2):537-40. doi: 10.1016/j.bmcl.2009.11.106. Epub 2009 Nov 26.

Proposed structural basis of interaction of piperine and related compounds with monoamine oxidases.

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  • 1Department of Pharmacology, Tennis Court Road, University of Cambridge, CB2 1PD, United Kingdom.


Several studies have revealed piperine and a few related compounds as potent inhibitors of monoamine oxidases without delineating the underlying mechanism. Using in silico modelling, we propose a structural basis of such activity by showing that these compounds can successfully dock into the inhibitor binding pockets of human monoamine oxidase isoforms with predicted affinities comparable to some known inhibitors. The results therefore suggest that piperine can be a promising lead for developing novel monoamine oxidase inhibitors.

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