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Eur J Neurol. 2010 Apr;17(4):562-6. doi: 10.1111/j.1468-1331.2009.02853.x. Epub 2009 Nov 24.

Cerebrospinal fluid and serum antibodies against neurofilaments in patients with amyotrophic lateral sclerosis.

Author information

1
First Faculty of Medicine, Institute of Medical Biochemistry, Charles University, Prague, Czech Republic. lfial@lf1.cuni.cz

Abstract

BACKGROUND:

The aim of the study was to assess autoimmune involvement in amyotrophic lateral sclerosis (ALS).

METHODS:

We measured IgG antibodies against light (NFL) and medium (NFM) subunits of neurofilaments using ELISA in paired cerebrospinal fluid (CSF) and serum samples from 38 ALS patients and 20 controls.

RESULTS:

Serum levels of anti-NFL were higher in ALS patients than in controls (P < 0.005). Serum anti-NFL antibodies and intrathecal anti-NFM antibodies were related to patient disability (serum anti-NFL: P < 0.05; intrathecal anti-NFM: P < 0.05). Anti-NFL levels were significantly correlated with anti-NFM levels in ALS (P < 0.001) and the control group (P < 0.0001) in the CSF, but not in serum. Anti-NFL and anti-NFM antibodies significantly correlated between serum and CSF in the ALS group (anti-NFL: P < 0.0001; anti-NFM: P < 0.001) and in the control group (anti-NFL: P < 0.05; anti-NFM: P < 0.05).

CONCLUSIONS:

Autoimmune humoral response to neurocytoskeletal proteins is associated with ALS.

[Indexed for MEDLINE]

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