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Proteins. 2010 Apr;78(5):1266-81. doi: 10.1002/prot.22645.

PRIMO/PRIMONA: a coarse-grained model for proteins and nucleic acids that preserves near-atomistic accuracy.

Author information

1
Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, Michigan, USA.

Erratum in

  • Proteins. 2010 Jul;78(9):2187.

Abstract

The new coarse graining model PRIMO/PRIMONA for proteins and nucleic acids is proposed. This model combines one to several heavy atoms into coarse-grained sites that are chosen to allow an analytical, high-resolution reconstruction of all-atom models based on molecular bonding geometry constraints. The accuracy of proposed reconstruction method in terms of structure and energetics is tested and compared with other popular reconstruction methods for a variety of protein and nucleic acid test sets.

PMID:
19967787
PMCID:
PMC2822037
DOI:
10.1002/prot.22645
[Indexed for MEDLINE]
Free PMC Article

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