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Proc Natl Acad Sci U S A. 2010 Jan 26;107 Suppl 1:1718-24. doi: 10.1073/pnas.0909606106. Epub 2009 Dec 4.

Evolution in health and medicine Sackler colloquium: Evolution of the human lifespan and diseases of aging: roles of infection, inflammation, and nutrition.

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1
Davis School of Gerontology and the University of Southern California, Los Angeles, CA 90089, USA.

Abstract

Humans have evolved much longer lifespans than the great apes, which rarely exceed 50 years. Since 1800, lifespans have doubled again, largely due to improvements in environment, food, and medicine that minimized mortality at earlier ages. Infections cause most mortality in wild chimpanzees and in traditional forager-farmers with limited access to modern medicine. Although we know little of the diseases of aging under premodern conditions, in captivity, chimpanzees present a lower incidence of cancer, ischemic heart disease, and neurodegeneration than current human populations. These major differences in pathology of aging are discussed in terms of genes that mediate infection, inflammation, and nutrition. Apolipoprotein E alleles are proposed as a prototype of pleiotropic genes, which influence immune responses, arterial and Alzheimer's disease, and brain development.

PMID:
19966301
PMCID:
PMC2868286
DOI:
10.1073/pnas.0909606106
[Indexed for MEDLINE]
Free PMC Article
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