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Conf Proc IEEE Eng Med Biol Soc. 2009;2009:5946-9. doi: 10.1109/IEMBS.2009.5334759.

Neural signals in cortex and thalamus during brain injury from cardiac arrest in rats.

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Department of Biomedical Engineering, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.


Previous research has shown that a characteristic burst-suppression (BS) pattern appears in EEG during the early recovery period following cardiac arrest (CA). To study cortical and subcortical neural activity underlying BS, extracellular activity in the parietal cortex and the centromedian nucleus of the thalamus and extradural EEG were recorded in a rodent CA model. Preliminary results show that during the BS, the cortical firing rate is extraordinarily high, and that bursts in EEG correlate to dense spikes in cortical neurons. An unexpected and novel observation is that 1) thalamic activity reappears earlier than cortical activity following CA, and 2) the correlation coefficient of cortical and thalamic activity rises during BS period. These results will help elucidate the mechanism of brain recovery after CA injury.

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