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Conf Proc IEEE Eng Med Biol Soc. 2009;2009:224-7. doi: 10.1109/IEMBS.2009.5333970.

Analyzing 180 degrees turns using an inertial system reveals early signs of progression of Parkinson's disease.

Author information

1
Department of Neurology, Oregon Health & Science University, Portland, OR, USA. arash.salarian@ieee.org

Abstract

Changes in turning are one of the early motor deficiencies in Parkinson's Disease (PD). We have proposed a system based on wearable, inertial sensors and a novel automatic analysis algorithm that can assess 180 degrees turns. Twelve patients in early stages of PD and 14 age-matched healthy subjects were enrolled in this study. Inertial sensors were attached on shanks and sternum. Measurement protocol included walking on a straight pathway, turning 180 degrees and returning back. Subjects were measured 4 times, once every 6 months during an 18 months period. At the baseline, 9 subjects from each group repeated the test twice to assess test-retest reliability. Patients with mild PD had a very low Postural Instability Gait Difficulty (PIGD subscore of UPDRS III) score (average 0.67, min 0, max 3). The analysis showed that the patients had a significantly longer turning duration (2.18+/-0.43 vs. 1.79+/-0.27 seconds, p<0.02) and longer delay in their last step before initiating a turn (0.56+/-0.04 vs. 0.52+/-0.04 seconds, p<0.03). Estimated turning duration and other metrics had a high test-retest reliability (rho>0.85). Turning duration also showed a significant Group *Time interaction (p<0.03) during the longitudinal study highlighting early signs of the progression of the disease.

PMID:
19964471
PMCID:
PMC2954632
DOI:
10.1109/IEMBS.2009.5333970
[Indexed for MEDLINE]
Free PMC Article
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