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Semin Immunol. 2010 Apr;22(2):87-96. doi: 10.1016/j.smim.2009.11.001. Epub 2009 Dec 4.

A double-edged sword: the role of NKT cells in malaria and HIV infection and immunity.

Author information

1
Aaron Diamond AIDS Research Center, New York, NY 10016, United States. svasan@adarc.org <svasan@adarc.org>

Abstract

NKT cells are known to play a role against certain microbial infections, including malaria and HIV, two major global infectious diseases. NKT cells exhibit either protective or pathogenic role against malaria. They are depleted by HIV infection and have a direct pathogenic role against many opportunistic infections common in end-stage AIDS. This review discusses the various features of the interaction between NKT cells and malaria parasites and HIV, and the potential to harness this interaction for therapeutic and vaccine strategies.

PMID:
19962909
PMCID:
PMC3603358
DOI:
10.1016/j.smim.2009.11.001
[Indexed for MEDLINE]
Free PMC Article
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