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Neurosci Res. 2010 Mar;66(3):330-2. doi: 10.1016/j.neures.2009.11.012. Epub 2009 Dec 2.

Converging molecular pathways in human neural development and degeneration.

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1
Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, Sahlgrenska Academy at University of Gothenburg, Göteborg/Mölndal, Sweden. niklas.mattsson@neuro.gu.se

Abstract

Animal studies suggest that phosphorylation of microtubule-associated protein tau is a physiological way of destabilizing axons in the developing brain, promoting synaptic plasticity, while in the adult human brain tau phosphorylation is a specific sign of Alzheimer's disease. We here show, for the first time, that newborn human infants have extremely high levels of phosphorylated tau in their cerebrospinal fluid, and that these levels decrease during the first years of life. Tau phosphorylation in Alzheimer's disease may be a physiological response to Alzheimer-associated synaptotoxicity.

PMID:
19961883
DOI:
10.1016/j.neures.2009.11.012
[Indexed for MEDLINE]
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