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Bioorg Med Chem Lett. 2010 Jan 1;20(1):65-8. doi: 10.1016/j.bmcl.2009.11.030. Epub 2009 Nov 14.

SAR of N-phenyl piperidine based oral integrin alpha5beta1 antagonists.

Author information

1
Jerini AG, Invalidenstrasse 130, Berlin D-10115, Germany.

Abstract

Recently, a new class of selective integrin alpha5beta1inhibitors consisting of a heterocyclic based scaffold was published. Herein the SAR and pharmacokinetic profiles of N-phenyl piperidine derivatives are described.

PMID:
19959360
DOI:
10.1016/j.bmcl.2009.11.030
[Indexed for MEDLINE]

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