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J Comp Pathol. 2010 Jan;142 Suppl 1:S116-9. doi: 10.1016/j.jcpa.2009.10.002. Epub 2009 Dec 2.

Fading immune protection in old age: vaccination in the elderly.

Author information

1
Institute for Biomedical Aging Research, Austrian Academy of Sciences, Rennweg 10, 6020 Innsbruck, Austria. beatrix.grubeck@oeaw.ac.at

Abstract

The function of the immune system declines with age, leading to an increased occurrence and severity of infectious diseases and a decreased response to vaccines. As the thymus gradually loses its ability to replenish the population of naïve T cells, the memory and effector T cells increase in number and dominate the repertoire. The changes in the naïve and memory T cell pool that occur with ageing in man are discussed here, along with a brief update of the knowledge of B cell populations in the elderly.

PMID:
19959180
DOI:
10.1016/j.jcpa.2009.10.002
[Indexed for MEDLINE]

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