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Dev Comp Immunol. 2010 Apr;34(4):369-76. doi: 10.1016/j.dci.2009.11.010. Epub 2009 Dec 10.

Innate immunity and gut-microbe mutualism in Drosophila.

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Division of Life and Pharmaceutical Science, Department of Life Science, Department of Bioinspired Science, and National Creative Research Initiative Center for Symbiosystem, Ewha Woman's University, Seoul 120-750, South Korea.


Metazoan guts face a wide variety of microorganisms upon exposure to the environment, including beneficial symbionts, non-symbionts, food-borne microbes and life-threatening pathogens. Recent evidence has shown that the innate immunity of gut epithelia, such as anti-microbial peptide- and reactive oxygen species-based immune systems, actively participate in gut-microbe homeostasis by shaping the commensal community while efficiently eliminating unwanted bacteria. Therefore, elucidation of the regulatory mechanism by which gut innate immunity occurs at the molecular level will provide a novel perspective of gut-microbe mutualisms as well as of gut diseases caused by alterations in the innate immunity.

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