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Int J Pediatr Endocrinol. 2009;2009:624823. doi: 10.1155/2009/624823. Epub 2009 Feb 26.

Testicular adrenal rest tumours in congenital adrenal hyperplasia.

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Department of Paediatric Endocrinology (833), Radboud University Nijmegen Medical Centre, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands.


In adult patients with congenital adrenal hyperplasia (CAH), the presence of testicular adrenal rest tumours (TART) is an important complication leading to gonadal dysfunction and infertility. These tumours can be already found in childhood and puberty. In this paper, we review the embryological, histological, biochemical, and clinical features of TART and discuss treatment options.

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