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Exerc Sport Sci Rev. 2009 Oct;37(4):188-95. doi: 10.1097/JES.0b013e3181b7b7c5.

Exercise and insulin: Convergence or divergence at AS160 and TBC1D1?

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1
Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, 48109-2214, USA. gcartee@umich.edu

Abstract

Akt substrate of 160 kDa (called AS160 or TBC1D4) and TBC1D1, Rab GTPase-activating proteins that regulate glucose transport, become phosphorylated with exercise or insulin stimulation. Evidence suggests that this convergence may prove to be imperfect, and each stimulus will produce a unique phosphosignature, providing a plausible mechanism for their apparently unique and overlapping roles in exercise- and insulin-stimulated glucose transport.

PMID:
19955868
PMCID:
PMC2789346
DOI:
10.1097/JES.0b013e3181b7b7c5
[Indexed for MEDLINE]
Free PMC Article
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