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FEBS Lett. 1991 Feb 11;279(1):55-7.

The decreased level of casein kinase 2 in brain cortex of schizophrenic and Alzheimer's disease patients.

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All-Union Research Center for Mental Health, USSR Academy of Medical Sciences, Moscow.


The content of casein kinase 2 is considerably decreased in ribosome-free extracts of the frontal cortex of schizophrenic and Alzheimer's disease patients in comparison to normal brains as has been demonstrated by means of immunoblotting. The activity of casein kinase 2 towards endogenous substrates and casein is also diminished in the cases of mental pathologies examined. This phenomenon may explain the well-known aberrations in the phosphorylation of structural proteins of human brain which are intrinsic for the mental diseases.

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