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Clin Neuropsychol. 2010 Feb;24(2):189-202. doi: 10.1080/13854040903266910. Epub 2009 Nov 26.

Validity of the California Verbal Learning Test-II in multiple sclerosis.

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Department of Neurology, State University of New York (SUNY) at Buffalo, Buffalo, NY, USA.


Multiple sclerosis (MS) is a disease of the central nervous system where roughly 50% of patients exhibit cognitive impairment. Episodic memory defects are particularly common in MS and the California Verbal Learning Test: 2nd Edition (CVLT-II) was recommended for assessment in MS in a recently published consensus position paper. We investigated the validity of the CVLT-II in 351 MS patients and 69 demographically matched normal controls. MS patients performed significantly more poorly on 18 of the 23 measures examined. In addition to a general memory factor, factor analysis revealed five distinct factors conforming to measures of consolidation, primary/recency effect, proactive interference, and learning asymptote. The external validity of the CVLT-II was also supported by logistic regression analysis, which separated employed from work-disabled MS patients. We conclude that the CVLT-II is a valid test in MS and provides a rich constellation of verbal memory measures.

[Indexed for MEDLINE]

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