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AIDS. 2010 Feb 20;24(4):614-7. doi: 10.1097/QAD.0b013e32833556f3.

Immune and virological benefits of 10 years of permanent viral control with antiretroviral therapy.

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UPMC Univ Paris 06, INSERM, UMR945, AP-HP, Laboratoire d'Immunologie Cellulaire et Tissulaire, Hôpital Pitié-Salpêtrière, Paris, France.


The effects of a 10-year control of HIV replication without viral blips with antiretroviral therapy were examined in progressors. CD4 cell counts did not plateau but showed a continuous increase until the 10th year. Ultrasensitive techniques showed very low plasma HIV RNA and cell-associated DNA levels. Robust memory T cell responses to HIV-p24 were higher than in 3-year treated patients and comparable to those of Elite controllers, whereas interferon-gamma-producing HIV-specific T cells were infrequent. Long-term and efficient antiretroviral therapy provides continuous benefits both on the immune system and on the HIV reservoirs.

[Indexed for MEDLINE]

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