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Cell Stem Cell. 2009 Dec 4;5(6):610-23. doi: 10.1016/j.stem.2009.10.019.

SKPs derive from hair follicle precursors and exhibit properties of adult dermal stem cells.

Author information

1
Hospital for Sick Children, University of Toronto, ON, Canada. jeff.biernaskie@ucalgary.ca

Abstract

Despite the remarkable regenerative capacity of mammalian skin, an adult dermal stem cell has not yet been identified. Here, we investigated whether skin-derived precursors (SKPs) might fulfill such a role. We show that SKPs derive from Sox2(+) hair follicle dermal cells and that these two cell populations are similar with regard to their transcriptome and functional properties. Both clonal SKPs and endogenous Sox2(+) cells induce hair morphogenesis, differentiate into dermal cell types, and home to a hair follicle niche upon transplantation. Moreover, hair follicle-derived SKPs self-renew, maintain their multipotency, and serially reconstitute hair follicles. Finally, grafting experiments show that follicle-associated dermal cells move out of their niche to contribute cells for dermal maintenance and wound-healing. Thus, SKPs derive from Sox2(+) follicle-associated dermal precursors and display functional properties predicted of a dermal stem cell, contributing to dermal maintenance, wound-healing, and hair follicle morphogenesis.

PMID:
19951689
PMCID:
PMC2828150
DOI:
10.1016/j.stem.2009.10.019
[Indexed for MEDLINE]
Free PMC Article
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