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Adv Exp Med Biol. 2010;658:11-20. doi: 10.1007/978-1-4419-1050-9_2.

Activation of γδ T cells by bisphosphonates.

Author information

1
Bone and Musculoskeletal Research Programme, Institute of Medical Sciences, University of Aberdeen, Foresterhill, AB25 2ZD, Aberdeen, UK. k.thompson@abdn.ac.uk

Abstract

After decades of successful clinical use, the exact molecular mechanisms by which the anti-resorptive bisphosphonate drugs (BPs) exert their effects are now being revealed. In addition to their anti-resorptive effects, it is now apparent that nitrogen-containing BPs (N-BPs) have immunomodulatory properties. Specifically, these drugs activate immune cells called gamma, delta T lymphocytes. In this chapter we discuss the mechanism of gamma, delta T cell activation by N-BPs and propose that N-BPs may provide a safe and effective means for manipulating gamma,delta T cell activity in future immunotherapeutic approaches.

PMID:
19950011
DOI:
10.1007/978-1-4419-1050-9_2
[Indexed for MEDLINE]

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