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Dig Dis Sci. 2010 Feb;55(2):384-91. doi: 10.1007/s10620-009-1041-8.

Effect of meal ingestion on ileocolonic and colonic transit in health and irritable bowel syndrome.

Author information

1
Clinical Enteric Neuroscience Translational and Epidemiological Research, College of Medicine, Mayo Clinic, Charlton 8-110, 200 First St SW, Rochester, MN 55905, USA.

Abstract

BACKGROUND:

Postprandial symptoms in irritable bowel syndrome (IBS) have been associated with increased bowel contractility.

AIM:

To compare ileocolonic and colonic responses to feeding in health and IBS.

METHODS:

We prospectively analyzed data from separate research trials in 122 IBS patients and 41 healthy volunteers. Ileocolonic transit (ICT) was evaluated before (colonic filling [CF]3h) and immediately after (CF4 h) a standard lunch at 3 h 45 min, and 2 h thereafter. The colonic geometric center (GC) was calculated 2 h (GC6 h) after lunch ingested at 4 h (GC4 h) and directly after (GC8 h) a standard dinner ingested at 7 h 45 min.

RESULTS:

ICT immediately after eating was higher in IBS diarrhea predominant (IBS-D) patients than in the healthy cohort (23.1 +/- 2.4 vs. 17.5 +/- 2.8%, P = 0.059). ICT 2 h after lunch was similar between groups (P = 0.55). There was significant overall group differences in colonic transit 2 h post-lunch (P = 0.045), particularly in the IBS constipation predominant (IBS-C; GC6-GC4, delta 0.29 +/- 0.08) patients versus healthy volunteers (delta 0.56 +/- 0.12 GC units).

CONCLUSIONS:

After feeding, ICT is increased in IBS-D, whereas colonic transit is blunted in IBS-C.

PMID:
19949866
PMCID:
PMC2900583
DOI:
10.1007/s10620-009-1041-8
[Indexed for MEDLINE]
Free PMC Article

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