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Cancer Lett. 2010 May 28;291(2):237-45. doi: 10.1016/j.canlet.2009.10.018. Epub 2009 Nov 30.

Histone acetyltransferase p300 is a coactivator for transcription factor REL and is C-terminally truncated in the human diffuse large B-cell lymphoma cell line RC-K8.

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1
Department of Biology, Boston University, Boston, MA 02215, USA.

Abstract

Human c-Rel (REL) is a member of the NF-kappaB family of transcription factors. REL's normal physiological role is in the regulation of B-cell proliferation and survival. The REL gene is amplified in many human B-cell lymphomas and overexpression of REL can transform chicken lymphoid cells. In this report, histone acetyltransferase p300 enhanced REL-induced transactivation and interacted with REL both in vitro and in REL-transformed chicken spleen cells and the B-lymphoma cell line RC-K8, in which REL is constitutively active and required for proliferation. However, due to a deletion in the EP300 locus, only a C-terminally truncated form of p300 is expressed in RC-K8 cells. These results suggest a role for p300 in REL-mediated oncogenic activity in B lymphoma.

PMID:
19948376
PMCID:
PMC2849871
DOI:
10.1016/j.canlet.2009.10.018
[Indexed for MEDLINE]
Free PMC Article
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